Wednesday, February 28, 2024

Awareness! Bharat Biotech’s nasal vaccine is an Adenovirus vector vaccine, know its side effects

Date:

There has been a media-driven panic about COVID that is disconnected from reality.
Media outlets have done a poor job of providing context to covid and vaccine data.
No one talked about Covid for three months. This way, Covid and vaccination misinformation has led to people losing trust in mainstream media.

In the following paragraphs, www.qvive.in tries to make sure that you understand a few important facts.

What is Bharat Biotech’s intra-nasal Covid-19 vaccine Incovacc?

Bharat Biotech’s intra-nasal Covid vaccine Incovacc has received government approval for use as a booster dose in the country-wide mass inoculation program 

Bharat Biotech Incovacc is a “recombinant replication-deficient adenovirus vectored vaccine with a pre-fusion stabilized spike protein.”

Source: TimesofIndia

Bharat Biotech’s nasal vaccine is an adenovirus vector vaccine, made from a weakened version of the common cold virus that was originally sourced from chimpanzees. It has been modified to resemble and target the coronavirus. 

Along with the Covishield vaccine being developed by AstraZeneca and Oxford University and manufactured by the Serum Institute of India, Covaxin is being administered to Indians under a phased vaccination drive – the largest in the world.

The BBV154 intranasal vaccine

The SARS-CoV-2 virus generally enters the body via the nose. Intranasal vaccines are administered via the nose rather than injected into the skin. By conducting the vaccination in this way, the vaccine targets the virus present in the mucous in the nose, where the highest loads of the SARS-CoV-2 virus are also likely to present.

The nasal vaccine can be given via a spray, or a syringe with no needle or nose drops. According to a Times of India ( https://timesofindia.indiatimes.com/city/nagpur/nasal-covaxin-human-trials-begin-in-city/articleshow/81369733.cms )

( report, when the vaccine is administered with a nasal spray, it intercepts the virus locally in the nose) and prompts the immune system to make proteins in the blood known as antibodies that can combat an infectious organism.

Source: Firstpost ( https://www.firstpost.com/tech/science/bharat-biotechs-intranasal-vaccine-for-covid-19-everything-we-know-so-far-about-bbv154-9408701.html )

New method of nasal vaccine delivery could lead to better vaccines for HIV and COVID-19 by Researchers and Funded:

The research was funded by the National Institutes of Health’s National Institute of Allergy and Infectious Diseases; the National Cancer Institute; the Marble Center for Cancer Nanomedicine; the U. S. Army Research Office through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology; the Ragon Institute of MIT, Massachusetts General Hospital, and Harvard University; and the Bill and Melinda Gates Foundation.

( https://www.newswise.com/coronavirus/new-method-of-nasal-vaccine-delivery-could-lead-to-better-vaccines-for-hiv-and-covid-19/?article_id=776092 )

As far as vaccinations are concerned, here the data given below shows that vaccines have the same effects as Covid (seasonal flu). More sickness is attributed to nasal vaccination which will not protect you.

Facts from the CDC website:

Risks of a vaccine reaction

  • Headache, upper respiratory tract infection, stuffy nose, sore throat, abdominal pain, cough, nausea, diarrhea, fever, or joint pain can happen after adenovirus vaccine.
  • More serious problems including blood in the urine or stool, pneumonia, or inflammation of the stomach or intestines occur rarely after adenovirus vaccination.

As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injuries, or death.

( https://www.cdc.gov/vaccines/hcp/vis/vis-statements/adenovirus.html )

Adenovirus Vaccine Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 19, 2022.

Side effects include:

Upper respiratory tract infection, headache, nasal congestion, pharyngolaryngeal pain (sore throat), cough, arthralgia, GI effects (abdominal pain, nausea, diarrhea, vomiting).

General

The most common adverse events were upper respiratory tract infections, headache, nasal congestion, pharyngolaryngeal pain, cough, arthralgia, nausea, abdominal pain, diarrhea, and vomiting.

Respiratory

Very common (10% or more): Nasal congestion (15.3%), pharyngolaryngeal pain (12.9%), cough (12.4%)

Common (1% to 10%): Rhinorrhea[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain upper (14.6%), nausea (13.6%), diarrhea (10.2%)

Rare (less than 0.1%): Gastroenteritis, febrile gastroenteritis, gastritis, hematochezia

Other

Very common (10% or more): Upper respiratory tract infection (37.5%)

Common (1% to 10%): Pyrexia (temperature of 100.5F or higher), pain in extremity

Nervous system

Very common (10% or more): Headache (29.5%)

Musculoskeletal

Very common (10% or more): Arthralgia (17.3%)

Common (1% to 10%): Chills

Immunologic

Rare (less than 0.1%): Pneumonia, appendicitis

Genitourinary

Rare (less than 0.1%): Hematuria

Source: Drugs ( https://www.drugs.com/sfx/adenovirus-vaccine-side-effects.html )

Additional Information:

Amid Reports of Side Effects, Bharat Biotech Issues Fact Sheet for Who Should Avoid Getting Covaxin

A fact sheet shared on the company’s website said those suffering from allergies, fever, or a bleeding disorder, among other conditions, should take advice from their doctor/vaccine provider, and possibly steer clear of taking the Covaxin shot.

( https://www.news18.com/news/india/bharat-biotech-fact-sheet-covaxin-risk-3310409.html )

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